Which enzyme chemically links DNA fragments together (Okazaki fragments)?

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Multiple Choice

Which enzyme chemically links DNA fragments together (Okazaki fragments)?

Explanation:
This question tests how the lagging strand is built during DNA replication. Okazaki fragments are short pieces synthesized in the 5' to 3' direction, and they must be joined to form a continuous strand. The enzyme that does this is DNA ligase, which seals the nicks between fragments by forming phosphodiester bonds, effectively linking the pieces together. Helicase unzips the DNA, primase lays down RNA primers to start synthesis, and histones bind DNA to organize chromatin; none of these directly join the fragments. So the enzyme that chemically links the fragments is DNA ligase.

This question tests how the lagging strand is built during DNA replication. Okazaki fragments are short pieces synthesized in the 5' to 3' direction, and they must be joined to form a continuous strand. The enzyme that does this is DNA ligase, which seals the nicks between fragments by forming phosphodiester bonds, effectively linking the pieces together. Helicase unzips the DNA, primase lays down RNA primers to start synthesis, and histones bind DNA to organize chromatin; none of these directly join the fragments. So the enzyme that chemically links the fragments is DNA ligase.

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